Table 2.

The Effect of the GRS Instrument of Serum UA on Schizophrenia and the Effect of the GRS Instrument of Schizophrenia on Serum UA

Exposure	Outcome	Number of SNPs	Beta (SE)	OR (95% CI)	P-value	Qrs	P-Het
Serum UA	Schizophrenia	21a	−0.038 (0.027)	0.963 (0.913, 1.015)	0.154	24.191	0.234
Schizophrenia	Serum UA	44b	−0.039 (0.013)	0.962 (0.938, 0.987)	0.002*	46.941	0.314

Notes: *Statistically significant P-value. ^aSerum UA to schizophrenia MR after removal of the five SNPs with potential pleiotropic effects. ^bSchizophrenia to serum UA MR after removal of the SNP with potential pleiotropic effects.

Abbreviations: UA, uric acid; GRS, genetic risk score; SNP, single nucleotide polymorphism; Beta, beta coefficient; SE, standard error; CI, confidence interval; Qrs, heterogeneity test statistic; P-Het, P-value of heterogeneity of effect test.