Table 3.

Cochran’s Heterogeneity Statistic and MR Egger Intercept, Indicating Horizontal Pleiotropy for Two-Sample Bidirectional MR Analyses Between Serum UA and Schizophrenia

Exposure	Outcome	Number of SNPs	Cochran’s Heterogeneity Statistic (IVW)		Cochran’s Heterogeneity Statistic (MR Egger)		MR EGGER
			Q	P-value	Q	P-value	Intercept	SEe	P-value
Serum UA	Schizophrenia	26a	69.491	4.58E-06	68.708	3.42E-06	−0.003	0.006	0.606
Serum UA	Schizophrenia	21b	24.191	0.234	24.051	0.194	−0.001	0.004	0.742
Schizophrenia	Serum UA	45c	57.803	0.079	53.302	0.135	−0.014	0.007	0.063
Schizophrenia	Serum UA	44d	46.941	0.314	43.120	0.423	−0.013	0.006	0.060

Notes: ^aSerum UA to schizophrenia MR before removal of the five SNPs with potential pleiotropic effects. ^bSerum UA to schizophrenia MR after removal of the five SNPs with potential pleiotropic effects. ^cSchizophrenia to serum UA MR before removal of the SNP with potential pleiotropic effects. ^dSchizophrenia to serum UA MR after removal of the SNP with potential pleiotropic effects. ^eSE of the intercept.

Abbreviations: MR, Mendelian randomization; UA, uric acid; SNP, single nucleotide polymorphism; IVW, inverse variance weighted; SE, standard error.