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. 2020 Jan 27;39(5):e102622. doi: 10.15252/embj.2019102622

Figure 5. α‐Actinin‐1 E847K/E851K partially rescues open probability for CaV1.2 K1647E.

Figure 5

HEK293 cells were transfected with α11.2 with the K1647E mutation, α2δ‐1, and β2A plus α‐actinin‐1 WT or E847K/E851K before cell‐attached patch recording.
  • A
    Representative single CaV1.2 channel recordings of CaV1.2 K1647E with WT or E847K/E851K α‐actinin‐1.
  • B
    Mean assemble averages for all experiments for both combinations.
  • C–G
    Dot plots and means ± SEM for availability (C), NPo (D), Po (E), unitary current amplitude i (F), and mean of the current of a single channel calculated from the ensemble averages of each experiment (G) (**P < 0.01; unpaired t‐test; n = 16–30; see Table 6 for more details).