Table 3.
Influence factors of one-year euglycemia remission.
| Odds ratio | 95% CI for OR | P value | |
|---|---|---|---|
| (A) Overall analysis | |||
| Gender | 1.342 | 0.632~2.850 | 0.444 |
| Age | 0.992 | 0.961~1.024 | 0.616 |
| BMI at baseline | 1.055 | 0.949~1.172 | 0.323 |
| HDL-C at baseline | 0.446 | 0.123~1.613 | 0.218 |
| Mild hypoglycemia (3.0~3.9 mmol/L) | 2.184 | 1.015~4.699 | 0.046∗ |
| Mean insulin dose (IU/day) | 0.992 | 0.962~1.023 | 0.605 |
| FPG after treatment | 0.641 | 0.456~0.902 | 0.011∗ |
| PPG after treatment | 0.912 | 0.787~1.056 | 0.217 |
| AIR after treatment | 1.000 | 1.000~1.001 | 0.849 |
| HOMA-IR after treatment | 0.976 | 0.807~1.181 | 0.806 |
| (B) Stratified analysis | |||
| Gender | 1.439 | 0.673~3.077 | 0.348 |
| Men | |||
| Women | |||
| Age (years) | 0.901 | 0.588~1.380 | 0.633 |
| <45 | |||
| 45-55 | |||
| >55 | |||
| BMI at baseline (kg/m2) | 1.062 | 0.639~1.767 | 0.816 |
| <24 | |||
| 24-28 | |||
| >28 | |||
| HDL-C at baseline (mmol/L) | 0.623 | 0.305~1.269 | 0.192 |
| <1.0 | |||
| ≥1.0 | |||
| Total episodes of mild hypoglycemia | 1.593 | 1.153~2.201 | 0.005∗ |
| None | |||
| 1-2 | |||
| 3-5 | |||
| >5 | |||
| Mean insulin dose (IU/day) | 0.903 | 0.509~1.600 | 0.726 |
| <30 | |||
| 30-40 | |||
| >40 | |||
| FPG after treatment (mmol/L) | 0.661 | 0.442~0.989 | 0.044∗ |
| <5.0 | |||
| 5.0-6.0 | |||
| 6.1-7.0 | |||
| >7.0 | |||
| PPG after treatment (mmol/L) | 0.697 | 0.467~1.039 | 0.076 |
| <6.0 | |||
| 6.0-8.0 | |||
| 8.1-10.0 | |||
| >10.0 | |||
| AIR after treatment (pmol/L·10 min) | 1.333 | 0.718~2.472 | 0.362 |
| <0 | |||
| 0-430 | |||
| >430 | |||
| HOMA-IR after treatment | 1.271 | 0.666~2.426 | 0.466 |
| <2.25 | |||
| ≥2.25 |
∗ means P < 0.05. BMI: body mass index; FPG: fasting plasma glucose; PPG: postprandial plasma glucose; HDL-C: high-density lipoprotein cholesterol; AIR: acute insulin response; HOMA-IR: homeostasis model assessment of insulin resistance. The median levels of AIR and HOMA-IR were 430 pmol/L·10 min and 2.25, respectively. Age, BMI, HDL-C, total episodes of mild hypoglycemia, mean insulin dose, FPG, and PPG were stratified according to the characteristics of clinical indicators. AIR and HOMA-IR were stratified based on the median levels.