Box 1.

Investigations in Patients with Suspected Melkersson-Rosenthal Syndrome

History and Examination

Examination for enlarged nerves

Otitis media

Visual Acuity

Hearing

Suggested Investigations

Blood glucose, Complete blood counts, Erythrocyte sedimentation rate

Liver and renal function tests

CT scan of the head, MRI of the brain, Chest X-ray to rule out secondary conditions

Angiotensin converting enzyme (ACE) levels

Anti-nuclear Antibody (ANA) testing

Antineutrophilic cytoplasmic antibody (ANCA)

Thyroid function test

Slit lamp for uveitis

Brainstem evoked audiometry, visual evoked potentials

Nerve conduction studies of facial nerve

Investigations in specialized scenarios

Evaluation for tuberculosis

Karyotyping for Down’s syndrome

HLA testing for Ulcerative colitis and Crohn’s disease

C1 inhibitor deficiency test for hereditary angioneurotic edema

Next generation sequencing