Skip to main content
. 2019 Apr 15;27(8):1546–1561. doi: 10.1016/j.bmc.2019.02.051

Table 1.

Binding affinity (KD) values for compounds against M. tuberculosis H37Rv.

graphic file with name fx1.jpg

Compound R KD (μM)a Soret peak shift (nm)
Lead H 1968 ± 137 416.5–417.5
8b 4-Cl 26.8 ± 7.9 416.5–419
8c 4-Br 11.9 ± 2.1 416.5–421
8d 3,5-diCl 8.1 ± 0.4 416.5–419
8e 4-OCH3 42.0 ± 14.3 416.5–419.5
8f 4-CH2CH3 3.7 ± 0.1 416.5–423.5
8g 4-CH(CH3)2 1.6 ± 0.1 416.5–422.5
8h 4-C(CH3)3 1.2 ± 0.1 416.5–419.5
8i Pyridin-4-yl 39.2 ± 7.9 416.5–419.5
8j Pyridin-3-yl 489 ± 27 416.5–421.5
Fluconazole 8.6 ± 0.2
Clotrimazole 0.07 ± 0.01
cYY 5.8 ± 0.2
a

Compound 8a (R = 4-F) noted to undergo photo- and thermal-decomposition during this assay.