Skip to main content
. 2019 Apr 15;27(8):1546–1561. doi: 10.1016/j.bmc.2019.02.051

Table 2.

MIC values for compounds against M. tuberculosis H37Rv.

graphic file with name fx2.jpg

Compound R Mol.Wt. MIC (μg/mL) cLogPa
Lead H 346.469 50 3.56
8a 4-F 382.450 6.25 3.87
8b 4-Cl 415.359 6.25 4.67
8c 4-Br 504.261 6.25 5.21
8d 3,5-diCl 484.249 25 5.79
8e 4-OCH3 406.521 25 3.3
8f 4-CH2CH3 402.575 6.25 5.36
8g 4-CH(CH3)2 430.628 6.25 6.02
8h 4-C(CH3)3 458.681 6.25 6.97
8i Pyridin-4-yl 348.445 >100 0.88
8j Pyridin-3-yl 348.445 >100 0.88
Fluconazole 306.271 >100 0.87
Clotrimazole 344.837 20 5.97
cYY 326.347 – 1.26
a

cLogP was determined using Crippen’s fragmentation.