Table 2.
Potentially deleterious mutations in genes and gene subunits encoding Electron Transport Chain enzymes. List of all mutations found to be potentially harmful by PROVEAN (marked by a *). The full list of mutations is given in Supplementary Table S5.
| Gene | MTB amino acid change | MTB Lineage | MAF amino acid change | MAF Lineage |
|---|---|---|---|---|
| ndhA | Asn360Ser; Met325Thr; Gly229Val |
clade of L2, L1, L3 |
Ala341fs | L5 |
| pruB | Arg257Cys | L5 | ||
| qcrC | Lys228Gln | L6 | ||
| ctaB | Ala68Thr | L5, L6 | ||
| frdA | Gly16Asp | L5 | ||
| frdB | Ser157Leu | L4 Haarlem | ||
| atpG | Tyr220Ser | L5 | ||
| atpH | Gly403Asp; Ser434Leu |
L5 | ||
| atpD | Val371Ala | L2 | ||
| nuoD | Gly392Ala | clade of L4 LAM | ||
| nuoH | Gly5His; 6insArg | clade of L4 LAM | ||
| nuoF | Pro19Leu | L3 | ||
| Rv0249c | Thr17fs | clade of L1 | ||
| ald | Gln89fs; Asp198Val; Ala123;_Asp124del |
L5, L6 |