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. 2020 Mar;108:102422. doi: 10.1016/j.jaut.2020.102422

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Alarmin-induced genes and biological pathways potentially regulated by epigenetic modifications. Heatmap showing the differential expression at all time points of cytokine stimulation of (A) IFNβ and (B) IL-15 upregulated genes (log2 fold change >1, FDR ≤ 0.01) with concordant epigenomic changes (Epi+/Exp+). The number of Epi+/Exp + genes per cluster are indicated. (n = 8 samples per time point and condition). Network-based representation of enriched biological pathways identified by GSEA on Epi+/Exp + genes responding to (C) IFNβ or (D) IL-15 stimulation.