Fig. 5.

DEGs in immune mediated gastro intestinal diseases and risk loci for autoimmune diseases are enriched in IE-CTLs transcriptional clusters. (A) The enrichment for DEGs in CeD (left) or IBD (right) on each of the DEG clusters from IE-CTLs stimulated with cytokines was assessed by fisher exact test. The significance of the enrichment (-log10(FDR)) is shown in the X-axis (B) The overlap between autoimmune disease risk loci and the transcriptional response of IE-CTLs exposed to cytokines was calculated. Colors indicate the significance of the overlap between DEGs of clusters (Fig. 2) and genes in autoimmune risk loci. Diseases are shown on the X-axis and genes contributing to the overlap on the Y-axis. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)