FIG. 5.

Levels of serum biomarkers CK, LDH, AST, and ALT in SC and IV dosed mdx mice compared to VEH-dosed WT mice. Values are presented as mean ± SEM. Dots represent values obtained in individual mice (n = 14–15). Significance between the scrambled control and WT group was assessed using an unpaired two-tailed t-test (^####P < 0.0001). Significance between the mdx groups was assessed using ANOVA and Tukey's multiple comparison test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; LDH, lactate dehydrogenase.