Figure 2.

Bacterial persistence and burden. (A) Lung bacterial burdens in animals that were left untreated for 7 months compared with animals treated with a 12-week regimen of once-weekly isoniazid and rifapentine, which mirrored results found in (B) BAL. (C–F) Dissemination and extrathoracic bacterial burden were further measured in bronchial lymph nodes (C), spleen (D), kidneys (E), and liver (F). The number of sterile samples per the number of samples are indicated above each graph. *P > 0.05 and ****P > 0.0001 using Student’s t test. BrLN = bronchial lymph nodes.