. 2020 Jan 21;295(9):2804–2821. doi: 10.1074/jbc.RA119.011639

Table 1.

Heparin-binding proteins identified by LPHAMS

ID	Symbol^a	Protein name	Location	Cellular source	Heparin binding
Q80WJ7	MTDH^a,b	Protein LYRIC (metadherin)	Type II transmembrane	MLEC	?
P13504	IL1R1A	Interleukin-1 receptor type 1	Type I transmembrane	BMEC	?
Q86T13	CLEC14A	C-type lectin domain family 14 member A	Type I transmembrane	HUVEC	?
P43630	KIR3DL2	Killer cell immunoglobulin-like receptor 3DL2	Type I transmembrane	HUVEC	?
P23467–3	PTPRB	Receptor-type tyrosine-protein phosphatase β	Type I transmembrane	HUVEC	?
Q24JP5	TMEM132A	Transmembrane protein 132A	Type I transmembrane	HUVEC	?
P17948	FLT1^a	Vascular endothelial growth factor receptor 1	Type I transmembrane	HUVEC/BMEC	Yes (20)
P07996	THBS1^a	Thrombospondin-1	Type I transmembrane	HUVEC/BMEC	Yes (16 –18, 79)
Q14956	GPNMB	Transmembrane glycoprotein NMB	Type I transmembrane	U937	Yes (80)
Q06481	APLP2	Amyloid-like protein 2	Type I transmembrane	U937	?
Q92478	CLEC2B	C-type lectin domain family 2 member B	Type I transmembrane	U937	?
P35613	BSG^a	Basigin	Type I transmembrane	U937	?
Q9NPY3	CD93^a	Complement component C1q receptor	Type I transmembrane	U937	?
Q32NZ6	TMC5	Transmembrane channel-like protein 5	Polytopic membrane	BMEC	?
O95490	ADGRL2	Adhesion G-protein-coupled receptor L2	Polytopic membrane	HUVEC	?
Q96QV1	HHIP^a	Hedgehog-interacting protein	GPI anchor	HUVEC/MLEC	Yes (19)
P20908	COL5A1	Collagen α1(V) chain	Extracellular matrix	HUVEC	?
P05997	COL5A2^a	Collagen α2(V) chain	Extracellular matrix	HUVEC	?
P39060	COL18A1^a	Collagen α1(XVIII) chain	Extracellular matrix	HUVEC/BMEC	Yes (32)
P02751	FN1^a	Fibronectin	Extracellular matrix	HUVEC/BMEC/MLEC	Yes (81)
P98160	HSPG2	Basement membrane-specific heparan sulfate proteoglycan core protein	Extracellular matrix	HUVEC/BMEC/MLEC	Yes (29)
P27658	COL8A1	Collagen α1(VIII) chain	Extracellular matrix	HUVEC/MLEC	?
P01029	C4B^a	Complement C4-B	Secreted	BMEC	?
Q925I7	PDGFD	Platelet-derived growth factor D	Secreted	BMEC	?
Q9UHI8	ADAMTS1^a	A disintegrin and metalloproteinase with thrombospondin motifs 1	Secreted	HUVEC	Yes (24, 25, 83)
O75173	ADAMTS4^a	A disintegrin and metalloproteinase with thrombospondin motifs 4	Secreted	HUVEC	Yes (24, 25)
Q99988	GDF15^a	Growth/differentiation factor 15	Secreted	HUVEC	?
P01857	IGHG1	Immunoglobulin heavy constant γ1	Secreted	HUVEC	?
P04433	IGKV3–11	Immunoglobulin κ variable 3–11	Secreted	HUVEC	?
Q16363	LAMA4^a,b	Laminin subunit α-4	Secreted	HUVEC	Yes (30, 31, 84)
Q9Y4K0	LOXL2^a	Lysyl oxidase homolog 2	Secreted	HUVEC	?
Q13201	MMRN1	Multimerin-1	Secreted	HUVEC	?
Q9HB63	NTN4	Netrin-4	Secreted	HUVEC	?
P05121	SERPINE1	Plasminogen activator inhibitor 1	Secreted	HUVEC	Yes (85)
P50454	SERPINH1	Serpin H1	Secreted	HUVEC	?
Q8IWU5	SULF2^a	Extracellular sulfatase Sulf-2	Secreted	HUVEC	Yes (86)
O00622	CYR61	CCN family member 1	Secreted	HUVEC/BMEC	Yes (87, 88)
Q9H8L6	MMRN2^a	Multimerin-2	Secreted	HUVEC/BMEC	?
P9279	CTGF	Connective tissue growth factor	Secreted	HUVEC/BMEC/MLEC	Yes (21)
P51858	HDGF^a	Hepatoma-derived growth factor	Secreted	HUVEC/MLEC/U937	Yes (27, 28)
P07355	ANXA2^a	Annexin A2	Secreted	HUVEC/U937	Yes (33)
P14625	HSP90B1^a	Endoplasmin	Secreted	HUVEC/U937	Yes (89 –91)
P40224	CXCL12	Stromal cell-derived factor 1	Secreted	MLEC	Yes (92)
Q9CXI5	MANF	Mesencephalic astrocyte-derived neurotrophic factor	Secreted	MLEC/U937	?
P08311	CTSG^a	Cathepsin G	Secreted	U937	Yes (93, 94)
P08246	ELANE	Neutrophil elastase	Secreted	U937	Yes (95)
Q07021	C1QBP	Complement component 1 Q subcomponent-binding protein, mitochondrial	Secreted	U937	?
P06733	ENO1	α-Enolase	Secreted	U937	?
P61769	B2M	β2-Microglobulin	Secreted	U937	Yes (96)
P28799	GRN	Progranulin	Secreted	U937	Yes (97, 98)
P20160	AZU1^a	Azurocidin	Secreted	U937	Yes (58)
P47929	LGALS7	Galectin-7	Secreted	U937	?
Q9Y450	HBS1L^a	HBS1-like protein	Secreted	U937	?
P07339	CTSD	Cathepsin D	Secreted	U937	Yes (59)
P08567	PLEK	Pleckstrin	Intracellular	U937	?

^a Proteins with a predicted Cardin-Weintraub sequence are shown.

^b Data contain a predicted turn-based motif.