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. 2019 Nov 12;3(4):pkz055. doi: 10.1093/jncics/pkz055

Figure 2.

Figure 2.

Oncogenic signaling pathways involved in head and neck squamous cell carcinoma. Red star = loss of function; green star = activating alterations. AKT = PKB, protein kinase B; APC = adenomatous polyposis coli; ARID1A = AT-rich interactive domain-containing protein 1A; AT-rich domain = rich in adenine and thymine; BIRC2 = baculoviral inhibitor of apoptosis repeat-containing protein 2; BRAF = rapidly accelerated fibrosarcoma, protein B; CASP8 = caspase 8; CCND1 = cyclin D1; CDK4/6 = cyclin-dependent kinase 4 and 6; CDKN2A = cyclin-dependent kinase Inhibitor 2A; CSL = CBF1, centromere-binding factor 1; CTNNB1 = catenin beta-1 protein; CUL3 = cullin 3; E2F = E2 factor; EGFR = epidermal growth factor receptor; FADD = Fas-associated death domain; FBXW7 = F-box and tryptophan-aspartic acid dipeptide repeat domain-containing 7; FGFR = fibroblast growth factor receptor; GSK3b = glycogen synthase kinase 3 beta; HER2 = human epidermal growth factor receptor 2; HPV = human papilloma virus; HRAS = Harvey rat sarcoma viral; LRP = lipoprotein receptor-related protein; Mam = mastermind; MEK = MAPK/ERK Kinase; MLL2 = KMT2D, KMT2D = histone-lysine N-methyltransferase 2D; mTOR = mammalian target of rapamycin; NFE2L2 = nuclear factor, erythroid 2 like 2; NFkB = nuclear factor kappa-B; NICD = notch intracellular domain; PIK3CA = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PTEN = phosphatase and tensin homolog; RB1 = retinoblastoma; TCF = T-cell factor; TNF = tumor necrosis factor; TNFR = tumor necrosis factor receptor; TP53 = tumor protein 53; TRAF3 = TNF receptor-associated factor 3; WNT = wingless/int1.