Table 2.
Univariate HRs and 95% CI indexes for all prognostic signatures in postmenopausal women according to nodal status during years 0 to 10*
| Signature | Patient group |
|||
|---|---|---|---|---|
| Node-negative disease (n = 591) |
Node-positive disease (n = 227) |
|||
| HR = (95% CI) | C index (95% CI) | HR = (95% CI) | C index (95% CI) | |
| CTS5 | 1.99 (1.58 to 2.50) | 0.721 (0.668 to 0.774) | 1.63 (1.20 to 2.21) | 0.640 (0.554 to 0.726) |
| IHC4 | 1.95 (1.55 to 2.45) | 0.725 (0.665 to 0.785) | 1.33 (0.99 to 1.78) | 0.601 (0.511 to 0.690) |
| RS | 1.69 (1.40 to 2.03) | 0.667 (0.585 to 0.750) | 1.39 (1.05 to 1.85) | 0.603 (0.513 to 0.693) |
| BCI | 2.46 (1.88 to 3.23) | 0.762 (0.704 to 0.820) | 1.67 (1.21 to 2.29) | 0.652 (0.566 to 0.739) |
| ROR | 2.56 (1.96 to 3.35) | 0.764 (0.707 to 0.821) | 1.58 (1.16 to 2.15) | 0.636 (0.552 to 0.719) |
| EPclin | 2.14 (1.71 to 2.68) | 0.765 (0.716 to 0.814) | 1.69 (1.29 to 2.22) | 0.671 (0.590 to 0.752) |
*
BCI = Breast Cancer Index; CI = confidence interval; CTS5 = Clinical Treatment Score-5 y; EPclin = EndoPredict clinical score; HR = hazard ratio; IHC4 = immunohistochemical 4 protein test; ROR = PAM 50 Risk of Recurrence Score; RS = Oncotype DX Recurrence Score. All HRs indicate a change of 1 SD. Adapted from (3).