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. 2019 Dec 20;63(4):1528–1543. doi: 10.1021/acs.jmedchem.9b01787

Chart 1. Orexin Receptor Antagonists Almorexant 1, Suvorexant 2, Filorexant 3, Lemborexant 4, Daridorexant 5, MK-1064 6, Seltorexant 7, EMPA 8, SB-674042 9, GSK1059865 10, SB-334867 11, SB-408124 12, HTL6641 13, Pyridothiadiazinone Compound 14, ACT-462206 15, and Diazaspirodecane Compound 16.

Chart 1