Figure 1.

Overview of the OX₁ and OX₂–antagonist complex crystal structures. (a–e) Overview of the OX₁ and OX₂ StaR structures in complex with suvorexant. (a) View from the extracellular space of OX₁ in a surface representation (green) and suvorexant in a sphere representation with carbon, nitrogen, oxygen, and chlorine atoms colored yellow, blue, red, and green, respectively. (b) View of the OX₁ receptor in a cartoon representation from a plane parallel to the membrane colored as in panel (a): approximate membrane boundaries are shown, and TM helices and loops are labeled. (c) Overlay of the OX₁ and OX₂ structures in a cartoon representation; receptors are colored green and gold. (d) View of the OX₂ receptor in a cartoon representation from a plane parallel to the membrane colored as in panel (c): TM helices and loops are labeled, and suvorexant in a sphere representation is colored as in panel (a). (e) View from the extracellular space of OX₂ in a surface representation (gold) and suvorexant in a sphere representation colored as in panel (a).