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(a) Extracellular view of the OX2 StaR structure in complex with HTL6641 (13). (b–d) Extracellular views of the OX1 StaR structures in complex with compound 14, ACT-462206 (15), and compound 16, respectively. Ligands shown in a stick representation with carbon, nitrogen, oxygen, and fluorine atoms colored yellow, blue, red, and cyan, respectively. Ligand 2Fo–Fc electron density maps in blue mesh and contoured at 1.0σ.
