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. 2019 Jun 19;3(3):pkz042. doi: 10.1093/jncics/pkz042

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Associations between the presence of preoperative circulating tumor DNA and clinicopathological variables and oncologic outcomes. The percentage of patients with a positive marker is represented for the categories of the variables. Green: all studies reporting on the specific marker found statistically significant associations; orange: part of the studies found statistically significant and part found statistically nonsignificant (NS) associations; pink: all studies found statistically NS associations. The overall (OS) and disease-free survival (DFS) is presented for patients with a positive (+) and a negative (−) marker. # = no percentage of patients or median or mean OS or DFS provided, * = median, ** = mean. TNM = tumor (T), nodes (N), and metastases (M).