Figure 3.

lncRNA HOTAIR expression was regulated by STAT3. A, Online analysis using MatInspector indicated the protein target of HOTAIR; B, Luciferase reporter assay was employed to test the regulation of STAT3 on HPTAIR promoter; *P < .05 vs siNC. C, Protein levels of STAT3 were decreased after transfection of siRNA targeting STAT3 (si‐STAT3) in colon cancer cells; *P < .05 vs siNC. D, Expression of HOTAIR was significantly decreased when STAT3 was silenced (si‐STAT3); **P < .01 vs siNC. E, Expression levels of STAT3 were decreased after propofol treatment in both LOVO and SW480 cell lines. *P < .05 and **P < .01 vs Control