Table 2.
Characteristics of the propensity-matched cohorts of antibiotic users matching each of the different quintiles of prior antibiotic use to the lowest quintile
| Matched quintile of prior antibiotic use | ||||||||
|---|---|---|---|---|---|---|---|---|
| Reference (lowest) | Low | Reference (lowest) | Middle | Reference (lowest) | High | Reference (lowest) | Highest | |
| CPRD | ||||||||
| Total N antibiotic prescriptions | 623,627 | 623,627 | 825,352 | 825,352 | 690,334 | 690,334 | 438,474 | 438,474 |
| Age (mean) | 43.4 | 43.3 | 44.3 | 44.2 | 45.9 | 45.7 | 50.9 | 50.7 |
| Women (%) | 398,289 (63.9%) | 397,113 (63.7%) | 548,995 (66.5%) | 547,199 (66.3%) | 477,977 (69.2%) | 476,765 (69.1%) | 315,692 (72%) | 315,586 (72%) |
| Comorbidity score (%) | ||||||||
| Lowest (score 0) | 399,315 (64.0%) | 399,407 (64.0%) | 503,555 (61.0%) | 503,782 (61.0%) | 390,999 (56.6%) | 392,619 (56.9%) | 207,908 (47.4%) | 209,284 (47.7%) |
| Low (scores 1–2) | 180,224 (28.9%) | 179,917 (28.9%) | 255,728 (31.0%) | 255,218 (30.9%) | 232,981 (33.7%) | 231,525 (33.5%) | 170,068 (38.8%) | 169,353 (38.6%) |
| Middle (scores 3–4) | 33,581 (5.4%) | 33,681 (5.4%) | 50,506 (6.1%) | 50,647 (6.1%) | 50,596 (7.3%) | 50,269 (7.3%) | 45,536 (10.4%) | 45,106 (10.3%) |
| High (scores 5–6) | 7633 (1.2%) | 7697 (1.2%) | 11,400 (1.4%) | 11,515 (1.4%) | 11,583 (1.7%) | 11,696 (1.7%) | 11,042 (2.5%) | 10,856 (2.5%) |
| Highest (score 7+) | 2874 (0.5%) | 2925 (0.5%) | 4163 (0.5%) | 4190 (0.5%) | 4175 (0.6%) | 4225 (0.6%) | 3920 (0.9%) | 3875 (0.9%) |
| SAIL | ||||||||
| N antibiotic prescriptions (total) | 246,887 | 246,887 | 159,261 | 159,261 | 141,620 | 141,620 | 102,947 | 102,947 |
| Age (mean) | 36.1 | 36.0 | 36.9 | 36.6 | 38.6 | 38.3 | 43.8 | 43.4 |
| Women (%) | 149,856 (60.7%) | 149,799 (60.7%) | 102,248 (64.2%) | 101,854 (64%) | 92,545 (65.3%) | 92,484 (65.3%) | 68,444 (66.5%) | 68,816 (66.8%) |
| Comorbidity score (%) | ||||||||
| Lowest | 202,665 (82.1%) | 202,679 (82.1%) | 123,976 (77.8%) | 124,428 (78.1%) | 105,998 (74.8%) | 106,549 (75.2%) | 70,005 (68.0%) | 70,564 (68.5%) |
| Low | 33,020 (13.4%) | 33,000 (13.4%) | 25,466 (16.0%) | 25,193 (15.8%) | 25,397 (17.9%) | 25,004 (17.7%) | 22,815 (22.2%) | 22,407 (21.8%) |
| Middle | 8473 (3.4%) | 8493 (3.4%) | 7339 (4.6%) | 7177 (4.5%) | 7660 (5.4%) | 7498 (5.3%) | 7591 (7.4%) | 7490 (7.3%) |
| High | 2005 (0.8%) | 2015 (0.8%) | 1819 (1.1%) | 1804 (1.1%) | 1887 (1.3%) | 1914 (1.4%) | 1881 (1.8%) | 1850 (1.8%) |
| Highest | 724 (0.3%) | 700 (0.3%) | 661 (0.4%) | 659 (0.4%) | 678 (0.5%) | 655 (0.5%) | 655 (0.6%) | 636 (0.6%) |