Table 2.
The top 10 Bonferroni-significant CpGs from the meta-analysis on the association between continuous GA and offspring DNA methylation at birth adjusted for estimated cell proportions
| CpGID | Chr | Genomic coordinates | Gene (Illumina annotation) | Relation to island | Distance to nearest gene | UCSC known gene | Coefficient* | P value | Direction of effect in each cohort** |
|---|---|---|---|---|---|---|---|---|---|
| cg16103712 | 8 | 99,023,869 | MATN2 | OpenSea | 7355 | MATN2 | − 0.0030 | 2.70E−129 | --------------- |
| cg04685228 | 5 | 172,462,626 | OpenSea | 726 | ATP6V0E1 | − 0.0028 | 8.55E−109 | ------?-------- | |
| cg04276536 | 16 | 57,567,813 | CCDC102A | N_Shelf | 0 | CCDC102A | − 0.0012 | 1.20E−93 | ------?-------- |
| cg19744173 | 2 | 112,913,178 | FBLN7 | N_Shelf | 0 | FBLN7 | − 0.0016 | 4.91E−92 | --------------- |
| cg27518892 | 16 | 57,566,936 | CCDC102A | N_Shelf | 0 | CCDC102A | − 0.0018 | 1.29E−89 | --------------- |
| cg13924996 | 11 | 67,053,829 | ADRBK1 | S_Shore | 0 | ADRBK1 | − 0.0016 | 8.59E−89 | ------?-------- |
| cg04494800 | 6 | 149,775,853 | ZC3H12D | N_Shore | 1923 | ZC3H12D | − 0.0016 | 4.52E−82 | ------?-------- |
| cg27295118 | 14 | 22,902,226 | OpenSea | − 500 | AK125397 | − 0.0024 | 1.20E−81 | ------?-------- | |
| cg26433582 | 11 | 68,848,232 | TPCN2 | N_Shore | 917 | TPCN2 | − 0.0019 | 1.31E−81 | ------?-------- |
| cg18183624 | 17 | 47,076,904 | IGF2BP1 | S_Shore | 0 | IGF2BP1 | 0.0028 | 8.36E−80 | +++++++++++++++ |
*Coefficient corresponding to methylation change per additional day of gestational age
**Order of included cohorts in the meta-analysis: MoBa1, MoBa2, MoBa3, EDEN, EXPOSOMICS (Environage+PiccoliPlus+RHEA), CHS, IOWF2, Generation R, Project Viva, CBC (Hispanic), CBC (White), ALSPAC, PREDO, CHAMACOS and INMA.”?” Means that CpG was not measured in that cohort