Table 1.
Comparison of subunits in human (Hsa) and A. godoyi (Ago) ETC Complex I
| Core subunits | “Eukaryote-specific subunits” | “Metazoan-specific subunits” | |||
|---|---|---|---|---|---|
| Hsa | Ago | Hsa | Ago | Hsa | Ago |
| MT-ND1 | Nad1 | NDUFAB1 | SDAP | NDUFA3 | B9 |
| MT-ND2 | Nad2 | NDUFA1 | MWFE | NDUFA7 | B14.5a |
| MT-ND3 | Nad3 | NDUFA2 | B8 | NDUFA10 | CI-42k |
| MT-ND4 | Nad4 | NDUFA5 | B13 | NDUFB1 | n.d. |
| MT-ND4L | Nad4L | NDUFA6 | B14 | NDUFB2 | AGGG |
| MT-ND5 | Nad5 | NDUFA8 | PGIV | NDUFB4 | B15 |
| MT-ND6 | Nad6 | NDUFA9 | CI-39ka | NDUFB5 | n.d. |
| NDUFS2 | Nad7 | NDUFA11 | B14.7 | NDUFB6 | n.d. |
| NDUFS8 | Nad8 | NDUFA13 | B16.6 | NDUFB8 | ASHI |
| NDUFS3 | Nad9 | NDUFB3 | B12 | NDUFC1 | n.d. |
| NDUFS7 | Nad10 | NDUFB7 | B18 | NDUFC2 | B14.5b |
| NDUFS1 | Nad11 | NDUFB9 | B22 | NDUFV3 | n.d. |
| NDUFV1 | CI-51k | NDUFB10 | PDSW | n.d. | NUXMb |
| NDUFV2 | CI-24k | NDUFB11 | ESSS | n.d. | NUUMb |
| NDUFA12 | B17.2 | NDUFS5 | CI-15k | ||
| NDUFS4 | AQDQ | ||||
| NDUFS6 | CI-13kA | ||||
Subunits shown in bold are encoded in mtDNA. n.d., not detected. A. godoyi nomenclature is based on that of bovine CI [44]
aWe identified two distinct isoforms of this subunit in Andalucia, encoded by separate genes
bNUXM and NUUM (identified in fungi) were initially considered to be distant homologs of the human subunits NDUFB1 and NDUFC1, respectively [48], but more recently this conclusion has been disputed [49]