Table 3.
Odds ratio for cancer subtypes in relation to radiation doses received from CT scans in the overall population, by sex and age strata
| Patient characteristics | Thyroid cancer |
Leukemia |
NHL |
|||
|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | |
| Overall | ||||||
| With CT scans, n (%) | 886 (4) | 3693 (2) | 704 (5) | 4713 (4) | 962 (5) | 9207 (5) |
| Without, n (%) | 21 967 (96) | 224 837 (98) | 12 336 (95) | 125 687 (96) | 19 195 (95) | 192 354 (95) |
| OR (95% CI) | 2.55 (2.36 to 2.75) | 1.55 (1.42 to 1.68) | 1.05 (0.98 to 1.12) | |||
| aOR (95% CI) | 2.54 (2.35 to 2.74) | 1.54 (1.42 to 1.67) | 1.05 (0.98 to 1.12) | |||
| Female | ||||||
| With CT scans, n (%) | 673 (4) | 2596 (1) | 298 (6) | 1719 (3) | 430 (5) | 3978 (5) |
| Without, n (%) | 17 009 (96) | 174 224 (99) | 5086 (94) | 52 121 (97) | 8361 (95) | 83 923 (95) |
| OR (95% CI) | 2.76 (2.53 to 3.02) | 1.82 (1.60 to 2.07) | 1.09 (0.98 to 1.21) | |||
| aOR (95% CI) | 2.75 (2.52 to 3.01) | 1.81 (1.59 to 2.06) | 1.08 (0.98 to 1.20) | |||
| Male | ||||||
| With CT scans, n (%) | 213 (4) | 1097 (2) | 406 (5) | 2994 (4) | 532 (5) | 5220 (5) |
| Without, n (%) | 4958 (96) | 50 613 (98) | 7250 (95) | 73 566 (94) | 10 834 (95) | 108 431 (95) |
| OR (95% CI) | 2.04 (1.75 to 2.37) | 1.39 (1.25 to 1.55) | 1.02 (0.93 to 1.12) | |||
| aOR (95% CI) | 2.03 (1.74 to 2.37) | 1.38 (1.24 to 1.54) | 1.02 (0.93 to 1.12) | |||
| Aged younger than 35 y | ||||||
| With CT scans, n (%) | 30 (1) | 94 (0.3) | 22 (2) | 44 (0.4) | 12 (1) | 50 (0.4) |
| Without, n (%) | 3433 (99) | 34 877 (99.7) | 1158 (98) | 11 694 (99.6) | 1144 (99) | 11 622 (99.6) |
| OR (95% CI) | 3.15 (2.07 to 4.79) | 5.18 (3.06 to 8.75) | 2.72 (1.43 to 5.19) | |||
| aOR (95% CI)* | – | – | – | |||
| Aged 36–45 y | ||||||
| With CT scans, n (%) | 82 (1.5) | 200 (0.4) | 20 (1) | 72 (0.5) | 41 (2.2) | 141 (0.7) |
| Without, n (%) | 5353 (98.5) | 54 098 (99.6) | 1498 (99) | 15 061 (99.5) | 1846 (97.8) | 18 772 (99.3) |
| OR (95% CI) | 4.04 (3.10 to 5.26) | 2.86 (1.71 to 4.79) | 3.05 (2.13 to 4.37) | |||
| aOR (95% CI)* | – | – | – | |||
| Aged 45 y or older | ||||||
| With CT scans, n (%) | 774 (5) | 3399 (2) | 662 (6) | 4597 (4) | 909 (5) | 9016 (5) |
| Without, n (%) | 13 181 (95) | 135 862 (3) | 9680 (94) | 98 932 (96) | 16 205 (95) | 161 960 (95) |
| OR (95% CI) | 2.41 (2.22 to 2.62) | 1.49 (1.37 to 1.62) | 1.01 (0.94 to 1.08) | |||
| aOR (95% CI)* | – | – | – | |||
*
Odds ratio was estimated by conditional logistic regression. Adjusted odds ratio was estimated by multiple conditional logistic regression including age and sex. The sex variable was exact matched; therefore, the adjusted odds ratio was the same as the odds ratio. aOR = adjusted odds ratio; CI = confidence interval; CT = computed tomography; NHL = non-Hodgkin lymphoma; OR = odds ratio.