Table 3.

Correlation of blood urea with the anthropometric, biochemical, and renal biomarkers in gentamicin-induced nephrotoxicity regarding the effect of irbesartan compared with the control

Variables	Control		G + S		G + I
	r	P	r	P	r	P
Serum cr. (mg/dL)	0.62	0.33	0.99	0.01¶	0.96	0.01¶
GFR (mL/min/1.73)	0.33	0.50	−0.91	0.04¶	0.89	0.04¶
MDA (ng/mL)	0.57	0.23	0.99	0.008*	0.99	0.01¶
SOD (pg/mL)	0.72	0.09	−0.99	0.001*	−0.98	0.02¶
GSH (µg/mL)	0.45	0.43	−0.89	0.09	−0.77	0.08
KIM-1 (pg/mL)	0.86	0.06	0.89	0.02¶	0.85	0.01¶
Cys-C (mg/dL)	0.66	0.15	0.98	0.015¶	0.96	0.01¶

r: correlation level; P: level of significance; G + S: gentamicin + saline; G + I: gentamicin + irbesartan; A: control vs G + S; B: control vs G + I; C: G + I vs G + S BMI: body mass index; E-GFR: estimated glomerular filtration rate; MDA: malondialdehyde; SOD: superoxide dismutase; GSH: glutathione reductase; KIM-1: kidney injury molecule-1; NGAL: neutrophil gelatinase-associated lipocalin *P<0.01; ¶P<0.05, unpaired t test