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. 2020 Feb 5;10(3):414–426. doi: 10.1002/2211-5463.12796

Table 1.

Parameters of Escherichia coli isolates. CD patients and non‐IBD donors of feces and blood used in the study.

  Patient Isolate CL max, Lum, LB Px, μmol·g−1 dry weight Cat, nmol H2O2·g−1 dry weight Groups of the isolates according to their CL‐stimulating capacity

Escherichia coli genome

29

Escherichia coli phylogroup b 29 F (ANS). a.u. F (DMC). a.u. Localization 30 Clinical activity 30 Endoscopic activity 31 Type of material for preparation of isolates E. coli DNA copies per ml aspirate/fecesa
E. coli donors CD G G 24 ± 7 36 ± 1.8 77.0 ± 4.1 2 RCE05‐01 D 32.8 26.2 Ileitis–jejunitis Severe disease 9 Feces

2.1 x 109

stool

A A1 2.5 ± 1 51.89 ± 3.2 108.4 ± 5 1 RCE01‐05 A 41 ± 6 105 ± 9 Ileitis Mild disease 10 Lumen

1.25 x 107

stool

A2 3 ± 1.2 59.9 ± 2.5 60.8 ± 4.1 1 RCE01‐02 A Ileum biopsy
A3 2.8 ± 1.5 86.4 ± 3.3 86.9 ± 5 1 RCE01‐06 A Feces
A4 3.5 ± 1.3 51.0 ± 2.1 24.4 ± 3.7 1 RCE01‐04 A Lumen
B B1 42.3 ± 12 28.7 ± 3 16.7 ± 2 3 RCE03‐01 D 24 ± 3 5 ± 3 Ileocolitis Moderate disease 14 Ileum biopsy

2.8 x 105

aspirate

B2 61.2 ± 10 22.1 ± 2 14.4 ± 3.2 3 RCE03‐02 D
M M1 14 ± 6 33.7 ± 3.4 14.4 ± 1.6 1 RCE06‐01 B2 30 ± 6 85 ± 12 Ileocolitis Mild disease 15 Lumen

2 x 105

aspirate

M2 18 ± 6 30.0 ± 1.8 8.3 ± 2.1 1 RCE06‐02 B2
M3 11.8 ± 5 73.8 ± 2.2 33.8 ± 3.7 2 RCE06‐03 B2
M4 8 ± 3 43.7 ± 2.5 13.1 ± 2.4 2 RCE06‐04 B2
M5 3.2 ± 2 39.7 ± 3.3 11.5 ± 3.5 2 RCE06‐05 B2
Z Z 31 ± 6 20.8 ± 2.8 78.6 ± 5 3 RCE07‐01 A 20.2 25.5 Ileocolitis Remission 3 Lumen

1.3 x 108

aspirate

V V1 9 ± 2.7 20.1 ± 2.4 273.1 ± 3 1 RCE02‐02 B1 21 ± 5 36 ± 8 Ileocolitis Mild disease 13 Lumen

5 x 104

aspirate

V2 41.8 ± 14 26.7 ± 1.8 175.8 ± 12 2 RCE02‐01 B1
V3 15.1 ± 4 25.8 ± 3.5 150.3 ± 8.1 2 ‐ ‐
V4 17.6 ± 4 38.0 ± 3.2 158.1 ± 6.3 3 RCE02‐03 B1
P P1 18.7 ± 5 18.8 ± 2.6 105.5 ± 15 1 RCE04‐01 A 35 ± 15 33 ± 9 Ileocolitis–perianal Severe disease 0 Lumen

5.2 x 104

aspirate

P2 12.2 ± 5 40.9 ± 3.6 130.0 ± 3.5 1 RCE04‐02 A
P3 7.2 ± 3 45.5 ± 2.8 170.4 ± 8 2 RCE04‐03 A
P4 9.7 ± 3 45.5 ± 3.6 180.0 ± 10 2 RCE04‐04 A
P5 20.4 ± 8 24.7 ± 3 125.1 ± 8 2 RCE04‐05 A Ileum biopsy
P6 10.5 ± 5 32.9 ± 2.7 130.1 ± 7 2 RCE04‐06 A
Healthy C C 59 ± 13 3.2 ± 0.7 29.1 ± 0.6 3   15 16   No IBD 0 Lumen

4 x 102

aspirate

h‐1 H1 41.6 ± 5         No IBD   Feces  
h‐2 H2 10 ± 3.2         No IBD   Feces  
h‐3 H3 58.5 ± 5.1         No IBD   Feces  
h‐4 H4 5 ± 2.1         No IBD   Feces  
Blood donors Blood donor 1   No IBD      
Blood donor 2   No IBD      
Blood donor 3   No IBD      
Blood donor 4   No IBD      
Blood donor 5   No IBD      

Values are given as M ± SD, where M is mean value between the isolates from one patient. SD—standard deviation.

References to the genomes of E. coli isolates are given according to Ref. 29

Localization, clinical activity, and endoscopical activity of inflammation were determined according to Ref. 30, 31

a

The amount of E. coli DNA was measured in feces or aspirate even if some E. coli strains for study were sampled from biopsy. From CD samples, only those with E. coli DNA content 1 × 104 copies per ml and above were selected for the study

b

Phylogroups of E. coli isolates were determined from their genomes (sequencing performed in our previous work 29).