Table 1.

Selection of Nanostring Genes for Skin Biopsy Analysis

Myelin Genes
PMP22	MPZ
-exonla	MAG
-exonlb	MBP
CLDN19	PMP2
MAL	PLP1
CD9	CNTF
IL16	PRX
AATK	NDRG1
L1CAM	SOX10
UGT8	EGR2
GPM6A	S100B
GPR37L1	DHH
Injury Genes
GDNF	OLIG1
SHH	BDNF
RUNX2	HMGA2
FGF5	CCL2
GFAP	UCN2
TMPRSS5
CMT1A Genes
POU3F1	NGFR
CXCL14	ID2
EDNRB	SOX4
SOX5	CUEDC2
TTYH1	BZW2
PLEKHA1
Stable Genes
GPM6B	CNP
CADM4	PLLP
PLEKHB1	LGI4
NR4A2	VGLL3
ERBB2	ERBB3
GLDN

Table 1. Custom Nanostring panel design.

The indicated list of genes were submitted to Nanostring for capture/detection probe design. Indicated categories are major myelin genes, genes induced in Schwann cells after nerve injury, genes shown to be induced rodent CMT1A models, and also Schwann cell genes that are relatively unchanged in nerve injury and/or neuropathy model profiles. Most genes were chosen based on evidence that their expression was Schwann cell-specific using published profiles of sorted cells and/or specific to human tibial nerve. Many peripheral nerve genes are also expressed in oligodendrocytes in the CNS. The complete list of genes and Refseq accession number used for probe design is in Supplemental Table 1.