Validation of regulatory effect of rs2927438 on gene expression in PBMC. (A–D) rs2927438 showed significant association with the expression levels of ZNF226 (p = 0.0084), PVRL2 (p = 0.0024), and KLC3(p = 0.0037), as well as a trend of association with ZNF222 expression (p =0.0795). Individuals with an AA genotype had higher expression of ZNF226 (A), PVRL2 (B), and ZNF222 (D), but lower expression of KLC3 (C). Data were retrieved from SNPExpress (http://igm.cumc.columbia.edu/SNPExpress/; PBMC, N = 80) (Heinzen et al.,2008). Abbreviation: PBMC, peripheral blood mononuclear cells.