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. 2015 Sep 22;2015(9):CD001191. doi: 10.1002/14651858.CD001191.pub4

Comparison 3. Rivastigmine 20 cm2 patch (17.4 mg/day) versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 ADAS‐Cog (change from baseline at 24 weeks) ITT 1 543 Mean Difference (IV, Fixed, 95% CI) ‐2.6 [‐3.72, ‐1.48]
2 TMT‐A (change from baseline at 24 weeks) ITT 1 496 Mean Difference (IV, Fixed, 95% CI) ‐14.2 [‐24.11, ‐4.29]
3 clock drawing (change from baseline at 24 weeks) ITT 1 520 Mean Difference (IV, Fixed, 95% CI) 0.2 [‐0.34, 0.74]
4 MMSE (change from baseline at 24 weeks) ITT 1 543 Mean Difference (IV, Fixed, 95% CI) 0.90 [0.32, 1.48]
5 ADCS‐ADL (change from baseline at 24 weeks) ITT 1 544 Mean Difference (IV, Fixed, 95% CI) 2.3 [0.52, 4.08]
6 NPI‐12 (change from baseline at 24 weeks) ITT 1 544 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐2.88, 1.68]
7 withdrawals before end of treatment at 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 1.90 [1.22, 2.97]
8 at least one adverse event by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 2.28 [1.64, 3.16]
9 withdrawals due to an adverse event before end of treatment at 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 1.80 [0.93, 3.46]
10 at least one adverse event of dizziness by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 3.14 [1.31, 7.50]
11 at least one adverse event of nausea by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 5.12 [2.85, 9.22]
12 at least one adverse event of vomiting by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 6.77 [3.38, 13.53]
13 at least one adverse event of weight decrease by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 6.12 [2.09, 17.92]
14 at least one adverse event of decreased appetite by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 5.19 [1.49, 18.12]
15 at least one adverse event of headache by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 2.66 [0.94, 7.56]
16 at least one adverse event of asthenia by 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 3.05 [0.82, 11.38]
17 deaths before end of treatment at 24 weeks 1 605 Odds Ratio (M‐H, Fixed, 95% CI) 1.67 [0.40, 7.06]
18 NPI‐D carer distress scale (change from baseline at 24 weeks) ITT 1 544 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐1.07, 1.07]