Table 1.
Parameter values used in simulations of 2010 AusVaxSafety signal detection
| AEFI | Parameter |
Scenario 1
2018 AEFI rates (%) |
Scenario 2
Conservative 2010 AEFI rates (%) |
Scenario 3
Ultra-conservative 2010 AEFI rates (%) |
| Fever | Expected rate | 3 | 20 | 30 |
| Maximum acceptable rate | 10 | 40 | 50 | |
| Observed rate and 95% CI (Fluvax) | 56.5 (49.4 to 63.3) | |||
| Observed rate and 95% CI (other brands) | 17.3 (10.7 to 25.7) | |||
| Medical attendance | Expected rate | 1 | 4 | 6 |
| Maximum acceptable rate | 3 | 8 | 10 | |
| Observed rate and 95% CI (Fluvax) | 16.4 (8.8 to 27.0) | |||
| Observed rate and 95% CI (other brands) | 2.0 (0.2 to 7.1) | |||
AEFI, adverse events following immunisation.