Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Directed acyclic graph (DAG) representing the natural indirect effect (that is mediated by changes in bone marrow lesion, synovitis, patella and wrist sensitization, or depressive symptoms; X to Y pathway through M) and the natural direct effect (that is not mediated; X to Y pathway not passing through M) of weight loss on knee pain improvement.
BML, bone marrow lesion; PPT, pressure pain threshold; CES-D, Center for Epidemiologic Studies Depression scale
