TABLE 2.

Estimates of the natural indirect and direct effects of massive (≥20%) weight loss on knee pain improvement.

Feature	Odds Ratio (95% Bootstrap CI)
	Natural Indirect Effect (Mediated)	Natural Direct Effect (Not Mediated)
BML
Worst score	1.01 (0.78, 1.28)	5.39 (1.43, 16.99)
Sum of scores	1.01 (0.72, 1.30)	4.70 (1.35, 15.22)
Synovitis
Worst score	1.03 (0.73, 1.45)	5.07 (1.38, 15.33)
Sum of scores	0.98 (0.73, 1.33)	4.87 (1.44, 13.82)
PPT
Patella	1.62 (0.89, 2.75)	2.47 (0.73, 7.71)
Wrist	1.15 (0.77, 1.77)	3.82 (1.10, 11.30)
CES-D	1.22 (0.77, 1.87)	4.08 (1.08, 13.17)

BML, bone marrow lesion; CI, confidence interval; PPT, pressure pain threshold; CES-D, Center for Epidemiologic Studies Depression scale