Table 3.
Selected analyses of markers showing association with disease activity. Mixed effects models included marker concentration as the dependent variable, disease activity as a dichotomous independent variable, the patient as the random effect, with or without current use of prednisone and other immunosuppressive drugs (“Meds”) as independent dichotomous variables. Numbers indicate beta-coefficients associating an increase (if > 0) or decrease (if <0) in marker concentration with active disease, with 95% confidence intervals in parentheses, and P-values. All marker values except ESR were ln-transformed. Therefore, the beta-coefficient for ESR represents absolute change (mm/hr), whereas for other markers, the beta-coefficient multiplied by 2.72 represents fold-change. Only analyses with P<0.1 are included in this table. Analyses with P<0.05 are shown in bold. For results of all analyses, see Supplementary Table 1.
| Marker | GCA | GCA Meds | TAK Meds | PAN | PAN Meds | EGPA | EGPA Meds | LVV | LVV Meds |
|---|---|---|---|---|---|---|---|---|---|
| ACE | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | −0.27(−0.57 −0.04) P=0.09 | −0.32(−0.64– −0.01) P=0.05 | ||
| BCA-1 | 0.23 (0.01– 0.45) P=0.04 | 0.33 (0.10 – 0.56) P=0.005 | ----------------- | ----------------- | ----------------- | 0.27 (−0.01 -0.55) P=0.06 | 0.34 (0.05 – 0.62), P=0.02 | 0.21 (0.03 – 0.38) P=0.02 | 0.24 (0.07 – 0.42) P=0.006 |
| CRP | 0.35 (0.01 – 0.70) P=0.05 | ----------------- | −0.47 (−1.02 – 0.07) P=0.09 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- |
| ESR | 10.6 (5.3 – 15.8) P=0.0001 | 10.3 (4.9 – 15.8) P=0.0003 | ----------------- | 8.12 (1.6 – 14.6) P=0.02 | 8.53 (1.79 – 15.3) P=0.01 | ----------------- | ----------------- | 7.86 (3.76 – 12) P=0.0002 | 7.69 (3.55 – 11.8) P=0.0003 |
| G-CSF | 0.45 (0.03 – 0.87) P=0.04 | 0.39 (−0.04 – 0.83) P=0.08 | ----------------- | ----------------- | ----------------- | 0.53 (0.15 – 0.92) P=0.007 | 0.62 (0.23 – 1.02) P=0.002 | ----------------- | ----------------- |
| GM-CSF | 0.31 (0.04 – 0.57) P=0.03 | 0.27 (−0.01 – 0.55) P=0.05 | ----------------- | ----------------- | ----------------- | 0.63 (0.21 – 1.06) P=0.004 | 0.75 (0.32 – 1.19) P=0.0009 | 0.21 (0.02 – 0.39) P=0.03* | 0.19 (0.01 – 0.38) P=0.04 |
| IL-6 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.45 (0.02 – 0.88) P=0.04 | 0.49 (0.04 – 0.94) P=0.03 | ----------------- | ----------------- |
| IL-15 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.44 (0.07 – 0.81) P=0.02 | 0.58 (0.2 – 0.95) P=0.003 | ----------------- | ----------------- |
| IL-18 | 0.21 (-0.01 - 0.43) P=0.06 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.14 (0.02 – 0.25) P=0.02 | 0.14 (−0.02 – 0.31) P=0.09 |
| IL-18BP | 0.14 (0.00 − 0.29) P=0.05 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.16 (−0.01 – 0.32) P=0.06 | 0.11 (−0.00 – 0.23) P=0.05 |
| IP-10 | −0.26 (−0.47 – −0.05) P=0.02 | −0.3(−0.52 – −0.08) P=0.008 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | −0.18(−0.37 – 0.01) P=0.06 |
| MMP-3 | ----------------- | ----------------- | ----------------- | −0.58 (−1.12 – −0.04) P=0.04 | −0.68 (−1.24 – −0.13) P=0.02 | ----------------- | ----------------- | ----------------- | ----------------- |
| Osteopontin | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.20 (−0.01 – 0.4) P=0.06 | ----------------- |
| PDGF-AB | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.32 (−0.02 – 0.66) P=0.06 | 0.34 (−0.00 – 0.69) P=0.05 | ----------------- | ----------------- |
| sIL-2Rα | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | 0.60(0.12 –1.08) P=0.01 | 0.68 (0.18 – 1.18) P=0.008 | ----------------- | ----------------- |
| TIMP-1 | 0.12 (0.02 – 0.21) P=0.02 | 0.13 (0.03 – 0.23) P=0.01 | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- | ----------------- |