Fig. 4. Osimertinib-resistant cell lines are cross-resistant to other EGFR-TKIs.
Osimertinib-resistant cell lines derived from PC-9 (A) or HCC827 (B) as indicated were seeded in 96-well plates and, on the second day, treated with different concentrations of the given EGFR-TKIs. After 3 days, cell numbers were estimated with the SRB assay. The data are means ± SDs of four replicate determinations.