Table 1.

Annotations for SNPs that showed significant and consistent impacts in both SH-SY5Y and SK-N-BE(2) cell lines by PASSPORT-seq

Region	Gene	SNP	MAF (%)	eQTL	RBP binding	Potential miRNA target
BLA	PEAK1	rs17381821	18	Yes		miR-3913-3pa
BLA	PNP	rs1079375	32	Yes
CE	HELQ	rs4693089	34	Yes	PABPC1, ELAVL1
CE	KIF1B	rs1065828	33	Yes	IGF2BP1
CE	KIF1B	rs1536262	45	Yes	IGF2BP1
CE	PACRGL	rs6812257	31	Yes	ELAVL1, PABPC1
CE	ZNF625	rs59816741	1	No
NAC	LYPD5	rs4525602	3	No
NAC	PCDHB16	rs2338530	10	Yes	PABPC1
NAC	PRLR	rs173627	24	No	PABPC1
NAC	SLC16A4	rs11120	18	Yes	ELAVL1, PABPC1	miR-200b-3pb, miR-200c-3pa, miR-374c-5pa, miR-429c, miR-4330b, miR-510-5pa, miR-512-5pb, miR-655-3pb, miR-8084a, miR-3942-3pc, miR-506-5pc, miR-5100b, miR-6074a, miR-889-3pc, miR-892c-5pa
NAC	SMPD4	rs10909567	38	Yes	IGF2BP1
NAC	SYT9	rs10732510	48	No		miR-3925-3pb, miR-136-5pc, miR-4695-3pa, miR-665a, miR-766-3pc
SFC	CA13	rs4617148	45	Yes	ELAVL1, PABPC1, IGF2BP1	miR-3125c, miR-3916c, miR-6859-5pa, miR-6866-5pa, miR-877-5pc, miR-4496c
SFC	CA13	rs4740047	42	Yes	ELAVL1, PABPC1, IGF2BP1
SFC	FKTN	rs2010861	13	Yes	ELAVL1, PABPC1	miR-6840-3pa
SFC	LRPAP1	rs11723071	20	Yes
SFC	LRPAP1	rs11729369	25	Yes
SFC	LRPAP1	rs13325	13	No
SFC	LRPAP1	rs140653273	1	No
SFC	MAVS	rs6515831	31	Yes		miR-4289a
SFC	PODN	rs899974	19	No
SFC	PPARA	rs10154348	7	Yes	ELAVL1, PABPC1, CELF1	miR-7155-5pa
SFC	SNX18	rs2565014	35	Yes	PABPC1	miR-4655-3pa miR-7848-3pa
SFC	UQCC1	rs3764732	14	No	PABPC1	miR-3922-5pa, miR-513c-5pb, miR-514b-5pc, miR-330-3pc, miR-371a-5pa, miR-371b-5pc, miR-372-5pa, miR-373-5pb, miR-616-5pc, miR-7109-3pa

Brain regions: BLA basolateral nucleus of the amygdala, CE central nucleus of amygdala, NAC nucleus accumbens, SFC superior frontal cortex. MAF minor allele frequency, eQTL whether the SNP had a significant eQTL for its gene in GTEx, RBP RNA-binding proteins whose binding sites overlapped the SNP, and miRNAs whose binding potential was changed by the alternative allele

^amiRNA expression unknown

^bmiRNA not expressed in brain

^cmiRNA expressed in brain