Skip to main content
. Author manuscript; available in PMC: 2020 Mar 2.
Published in final edited form as: J Leukoc Biol. 2019 Feb 28;106(1):83–93. doi: 10.1002/JLB.3MIR0918-354R

TABLE 2.

LncRNAs in Intracellular Immunity

LncRNA Species Function Reference
LincRNA-Cox2 Ms Both activates and suppresses cytokine expression downstream of TLR2 activation via interaction with SWI/SNF or hnRNPA/B/hnRNPA2/B1 respectively 58,59
THRIL Hu Promotes transcription of TNFα via hnRNPL 60
Lethe Ms Operates as a molecular decoy preventing NFκB localization to innate genes 61
LincRNA-EPS Ms Represses upregulation of a number of cytokines at homeostasis both in vitro and in vivo by recruiting hnRNPL 64
iNOS-AS Transcript Rt Basepair complements with the 3’UTR of iNOS mRNA, promoting its stability and iNOS translation 62
PACER Hu Interacts with the p50 subunit of NFκB to induce expression of COX2 84
AS-IL-1α Ms Supports recruitment and deposition of RNA Polymerase II to the Il1a coding locus 85
AS-IL-1β Ms Modulates H3K4me3 deposition at the promoter of the Il1b locus in a manner that suppresses transcription 86
Lnc13 Hu, Ms Transcript produced from a risk allele identified in GWAS studies of celiac disease that associates with Hdac1 and hnRNPD 87
FIRRE Hu Interacts with hnRNPU and promotes the stability of innate coding mRNAs 88