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. Author manuscript; available in PMC: 2020 Mar 2.
Published in final edited form as: J Leukoc Biol. 2019 Feb 28;106(1):83–93. doi: 10.1002/JLB.3MIR0918-354R

TABLE 3.

LncRNAs in Innate Antiviral Immunity

LncRNA Species Function Reference
NRAV Hs Downregulated in human epithelial cells following infection with Influenza A; suppresses the expression of ISGs including MXA potentially through interaction with ZONAB 65
NEAT1 Hs Induced by PolyI:C stimulation; required for the upregulation of IL-8 by modulating the formation of paraspeckles 66
LncRNA-ACOD1 Ms Induced by VSV in an IFN-independent manner; binds to and promotes the function of the metabolic enzyme GOT2 to support VSV replication 29
Lnc-Lsm3b Ms Induced late in VSV infection in an IFN-dependent manner; interacts with and inhibits RIG-I activation thus suppressing the induction of innate transcriptional programs 30
NeST Ms Modulates susceptibility to Theiler’s virus persistence by recruiting WDR5/MLL to the Ifng locus to bolster transcription in T cells 67
lncRHOXF1 Hu Suppresses Type I IFN and ISG transcription in human placental cells 89
GAS5 Hu Upregulated by HCV infection; inhibits HCV replication by directly binding the HCV protein NS3 90
LncITPRIP-1 Hu Induced by HCV infection in an IFNα-dependent manner; binds to and promotes MDA-5 function and the consequent induction of ISGs 91