Table 1.
Demographic and clinical characteristics of melanoma patients and histopathological features of tumors
|
n (%) |
|||
|---|---|---|---|
| FM | spMPM | P | |
| Characteristics of patients | N = 72 | N = 34 | |
| Sex | |||
| Males | 32 (44.4) | 19 (55.9) | 0.30 |
| Females | 40 (55.6) | 15 (44.1) | |
| Age at diagnosis | |||
| Age (years) [mean (range)] | 49 (15–81) | 41 (19–80) | 0.09 |
| ≤ 40 | 22 (30.6) | 16 (47.1) | 0.13 |
| > 40 | 50 (69.4) | 18 (52.9) | |
| Nevus count | |||
| ≤ 50 | 41 (56.9) | 12 (35.3) | 0.08 |
| > 50 | 28 (38.9) | 19 (55.9) | |
| Clinically atypical nevi | |||
| Yes | 18 (25.0) | 7 (20.6) | 1.00 |
| No | 49 (68.1) | 20 (58.8) | |
| Skin type | |||
| I | 7 (9.7) | 4 (11.8) | 0.68 |
| II | 40 (55.6) | 16 (47.1) | |
| III | 23 (31.9) | 13 (38.2) | |
| IV | 2 (2.8) | 1 (2.9) | |
| Hair color | |||
| Red/blond | 15 (20.8) | 11 (32.3) | 0.48 |
| Light brown | 31 (43.1) | 13 (38.2) | |
| Dark brown/black | 24 (33.3) | 10 (29.4) | |
| Eye color | |||
| Blue/green | 36 (50.0) | 15 (44.1) | 0.49 |
| Light brown | 24 (33.3) | 11 (32.3) | |
| Dark brown/black | 10 (13.9) | 8 (23.5) | |
| History of NMSC | |||
| Yes | 9 (12.5) | 1 (2.9) | 0.16 |
| No | 59 (81.9) | 32 (94.1) | |
| Number of primary melanomas | |||
| Single | 58 (80.6) | NA | NA |
| Multiple | 14 (19.4) | 34 (100) | 1.00 |
| Two melanomas | 13 (18.1) | 30 (88.2) | |
| Three melanomas | 1 (9.7) | 2 (5.9) | |
| Four melanomas | 0 (0) | 1 (2.9) | |
| Five melanomas | 0 (0) | 1 (2.9) | |
| Characteristics of tumors | N = 87 | N = 75 | |
| Breslow thickness | |||
| In situ | 32 (36.8) | 37 (49.3) | 0.20 |
| Invasive | 50 (57.5) | 37 (49.3) | |
| ≤ 1 mm | 70 (80.5) | 64 (85.3) | 1.00 |
| > 1 mm | 12 (13.8) | 10 (13.3) | |
| Median value (range) | 0.57 (0.22–5.00) | 0.60 (0.17–2.66) | 0.24 |
| Histopathological subtype | |||
| SSM | 74 (85.1) | 72 (96.0)* | NA* |
| NM | 0 (0) | 2 (2.6) | |
| LM/LMM | 6 (6.9) | 1 (1.3) | |
| ALM | 3 (3.4) | 0 (0) | |
| Others | 3 (3.4) | 0 (0) | |
| Anatomical site of melanoma | |||
| Head | 7 (8.0) | 2 (2.6) | < 0.01 |
| Trunk | 33 (37.9) | 47 (62.7) | |
| Extremities | 42 (48.3) | 26 (34.7) | |
| Palms or soles | 3 (3.4) | 0(0) | |
| Axial | 40 (46.0) | 49 (65.3) | 0.02 |
| Extremities | 45 (51.7) | 26 (34.7) | |
Numbers do not always add up to the total because of missing data.
ALM, acral lentiginous melanoma; FM, familial melanoma; LM/LMM, lentigo maligna/lentigo maligna melanoma; NA, not applicable; NM, nodular melanoma; NMSC, nonmelanoma skin cancer; spMPM, sporadic multiple primary melanoma; SSM, superficial spreading melanoma.
*
Significant difference in frequency distribution between FM and spMPM (P = 0.03) on comparing SSM versus others (NM, LM/LMM, ALM, spitzoid, occult).