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. Author manuscript; available in PMC: 2020 Mar 2.
Published in final edited form as: Chem Commun (Camb). 2018 Jun 19;54(54):7479–7482. doi: 10.1039/c8cc04251a

Fig. 4.

Fig. 4

Summary of cysteine adducts identified in EGFR tyrosine kinase based on tandem mass spectrometry analysis of tryptic digests of enzyme treated with compound 4. Pt-Modified cysteine residues are highlighted in red. [Pt(pn)]2+ is represented by an asterisk. The model octapeptide sequence, Q791–L798, in the hinge region between the N- and C-lobes, is highlighted in magenta. Structure adopted from PDB ID: 3W2S.