Figure 3: Ligand-binding sites of hsTRPM2, hsTRPM4, and faTRPM8.

The locations of available ligand-binding sites are boxed. Ca²⁺ is shown as black spheres, while other ligands and key residues involved in ligand binding are shown as sticks. The binding site of Ca²⁺ in (d) hsTRPM2, (e) hsTRPM4 and (f) faTRPM8. The hsTRPM2 binding sites of (g) ADPR1 in the MHR1/2 domain, (j) 8-Br-cADPR in the MHR1/2 domain, and (m) ADPR2 in the NUDT9-H domain. The binding sites in hsTRPM4 of (h) DVT1 at the kink of the rib helix and coiled-coil pole and of (k) DVT2 and (n) ATP at the interface of MHR1/2 and MHR3/4. The faTRPM8 binding sites of (i) icilin, (l) the menthol analog WS-12, and (o) PIP₂ in the TMD. Please see the report by Diver et al. for the AMTB and TC-I 2014 binding sites; the figures in this review were prepared before that report was out.