. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Cell Calcium. 2019 Nov 24;85:102111. doi: 10.1016/j.ceca.2019.102111

Tabel 1:

Summary of expression, function, related diseases and ligands of TRPM channels.

Name	Expression	Functions	Diseases	Ligands
TRPM1	Retina ON bipolar cells; Skin melanocytes.	Depolarization of the bipolar cell; suppress melanoma metastasis.	Congenital stationary night blindness.	Activation: pregnenolone sulphate Inhibition: Zn²⁺
TRPM2	Central nervous system; Immune cells; Pancreatic β cells	Core body temperature sensation; Oxidative sensation; Insulin secretion; Immune response.	Bipolar disorder; Ischaemia-reperfusion injury; Alzheimer’s disease.	Activation: ADPR, cADPR, 2′-deoxy-ADPR, 2′-P-ADPR, 3′-P-ADPR, 2-F-ADPR, AMPCPR, Ca²⁺ Inhibition: econazole, clotrimazole, flufenamic acid, N-(p-amylcinnamoyl)anthranilic acid, 2-APB, Scalardial, 3-MFA, 8-Br-cADPR, 8-Br-ADPR, 8-Ph-ADPR, 8-Ph-2′-deoxy-ADPR, 8-(3-acetylphenyl)-ADPR, 8-thiophenyl-ADPR, and more Other: PIP₂
TRPM3	Primary nociceptive neurons; Pancreatic beta-cell. Kidney	Glucose homeostasis; Heat sensation and inflammatory pain.	Visual epilepsy, retinal dystrophy.	Activation: pregnenolone sulphate, CIM0216. Inhibition: primidone
TRPM4	Heart, liver	Regulation of calcium oscillations after T cell activation, prevention of cardiac conduction disorders, Regulating smooth muscle contraction.	Brugada syndrome, Cardiac conduction defect.	Activation: Ca²⁺ Inhibition: ATP, ADP, AMP, DVT, 9-Phenanthrol.
TRPM5	Pancreatic beta-cells; tuft cells; solitary chemosensory cells.	Modulation of insulin secretion and sensory transduction in taste cells.	Beckwith-Wiedemann syndrome.	Activation: Ca²⁺, PIP2, Steviol glycosides, Rutamarin. Inhibition: TPPO
TRPM6	Kidney, intestine	Magnesium uptake and homeostasis in kidney and intestine.	Hypomagnesemia.	Activation: Mg²⁺ Inhibition: Ruthenium red
TRPM7	Ubiquitous.	Magnesium and Calcium homeostasis, cell viability.	Neuronal degenerative diseases.	Activation: Mg²⁺-ATP, breakdown of PIP2, increase in cAMP concentrations Inhibition: Mg²⁺, spermine, 2-APB, MnTBAP
TRPM8	Sensory neurons, prostate.	Cold sensation.	Inflammatory/neuropathic pain; prostate cancer.	Activation: menthol, icilin. Inhibition: WS-12, CPS-369.