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. 2020 Feb;30(2):173–184. doi: 10.1101/gr.253674.119

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© 2020 Li et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — DNA methylation across tissues. (A) DNA methylation metagene plots for post-bisulfite adapter tagging (PBAT) libraries. Plots indicate average DNA methylation values over 100-bp intervals. Vertical grid lines indicate 500-bp intervals. DNA methylation is measured as the proportion of methylated cytosines relative to total cytosines in each sequence context. (TSS) Transcription start site, (poly[A]) polyadenylation site. Published data from Park et al. (2016) and Kim et al. (2019). (B) DNA methylation metagene plot for conventional WGBS libraries; x- and y-axes as in A. (C) DNA methylation of 24-nt siRNA loci for PBAT libraries. Center line is median; box spans interquartile range; whiskers span 2.5th to 97.5th percentiles. (D) DNA methylation of 24-nt siRNA loci for conventional WGBS libraries, as in C; color code as in C. (E) Abundance of hypomethylated CHH differential methylated regions (hypo-CHH DMRs) in drm2 mutant relative to wild-type mature embryo. Abundance is measured as the percent of hypomethylated regions relative to total number of regions with sufficient read coverage for statistical significance. Dotted line indicates genome-wide average percent hypo-CHH DMRs. Color code as in C.