Table 2. GO and KEGG pathway enrichment analysis of downregulated DEGs in ED samples.
| Term | Description | Count in gene set | Gene ratio | P-value |
|---|---|---|---|---|
| GOTERM_BP_DIRECT | ||||
| GO:0030198 | Extracellular matrix organization | 22 | 6.452 | 1.28E−10 |
| GO:0007155 | Cell adhesion | 30 | 8.798 | 1.20E−08 |
| GO:0030574 | Collagen catabolic process | 12 | 3.519 | 2.61E−08 |
| GO:0060021 | Palate development | 12 | 3.519 | 1.65E−07 |
| GO:0001501 | Skeletal system development | 15 | 4.399 | 2.98E−07 |
| GO:0030199 | Collagen fibril organization | 9 | 2.639 | 5.20E−07 |
| GO:0007267 | Cell–cell signaling | 18 | 5.279 | 6.48E−06 |
| GO:0060326 | Cell chemotaxis | 9 | 2.639 | 2.80E−05 |
| GO:0046488 | Phosphatidylinositol metabolic process | 5 | 1.466 | 3.61E−05 |
| GO:0030335 | Positive regulation of cell migration | 13 | 3.812 | 1.90E−04 |
| GOTERM_MF_DIRECT | ||||
| GO:0005201 | Extracellular matrix structural constituent | 13 | 3.812 | 2.69E−09 |
| GO:0048407 | Platelet-derived growth factor binding | 7 | 2.053 | 1.50E−08 |
| GO:0005509 | Calcium ion binding | 29 | 8.504 | 1.32E−04 |
| GO:0008201 | Heparin binding | 12 | 3.519 | 1.74E−04 |
| GO:0008092 | Cytoskeletal protein binding | 7 | 2.053 | 2.26E−04 |
| GO:0005178 | Integrin binding | 9 | 2.639 | 6.76E−04 |
| GO:0003779 | Actin binding | 14 | 4.106 | 1.85E−03 |
| GO:0008009 | Chemokine activity | 6 | 1.76 | 1.94E−03 |
| GO:0008083 | Growth factor activity | 10 | 2.933 | 2.95E−03 |
| GO:0005518 | Collagen binding | 6 | 1.76 | 4.71E−03 |
| GOTERM_CC_DIRECT | ||||
| GO:0005615 | Extracellular space | 64 | 18.768 | 1.48E−12 |
| GO:0005576 | Extracellular region | 68 | 19.941 | 4.84E−11 |
| GO:0031012 | Extracellular matrix | 26 | 7.625 | 1.53E−10 |
| GO:0005578 | Proteinaceous extracellular matrix | 21 | 6.158 | 8.74E−08 |
| GO:0009986 | Cell surface | 30 | 8.798 | 1.74E−07 |
| GO:0070062 | Extracellular exosome | 87 | 25.513 | 2.27E−07 |
| GO:0005788 | Endoplasmic reticulum lumen | 15 | 4.399 | 1.01E−05 |
| GO:0005604 | Basement membrane | 10 | 2.933 | 1.18E−05 |
| GO:0005886 | Plasma membrane | 107 | 31.378 | 2.58E−05 |
| GO:0009897 | External side of plasma membrane | 15 | 4.399 | 3.23E−05 |
| KEGG_PATHWAY | ||||
| hsa04512 | ECM-receptor interaction | 13 | 3.812 | 3.56E−07 |
| hsa04151 | PI3K-Akt signaling pathway | 24 | 7.038 | 1.53E−06 |
| hsa04510 | Focal adhesion | 18 | 5.279 | 2.36E−06 |
| hsa04974 | Protein digestion and absorption | 12 | 3.519 | 3.03E−06 |
| hsa05200 | Pathways in cancer | 23 | 6.745 | 4.27E−05 |
| hsa05146 | Amoebiasis | 11 | 3.226 | 1.03E−04 |
| hsa05205 | Proteoglycans in cancer | 14 | 4.106 | 4.32E−04 |
| hsa04540 | Gap junction | 9 | 2.639 | 6.61E−04 |
| hsa04670 | Leukocyte transendothelial migration | 10 | 2.933 | 1.10E−03 |
| hsa04730 | Long-term depression | 7 | 2.053 | 1.93E−03 |
Notes.
Abbreviations
- GO
- Gene Ontology
- KEGG
- Kyoto Encyclopedia of Genes and Genomes
- DEGs
- differentially expressed genes
- ED
- erectile dysfunction