Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pyroptotic death evasion through gasdermin D (GSDMD). (A) GSDMD pores are exocytosed from the cell through the endosomal sorting complexes required for transport (ESCRT)-III machinery. (B) Caspase-3 and caspase-7 cleave the GSDMD-NT after D87, generating a nonfunctional protein fragment. (C) The 3C protease of enterovirus 71 cleaves the GSDMD-NT at a noncanonical site, generating an inactive NT fragment.
