Comparison 3. Beta‐lactamase inhibitor combination versus any other regimen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Treatment failure	12		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides	6	495	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.70, 1.64]
1.2 Penicillin plus beta‐lactamase inhibitor versus cephalosporins	2	52	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.26, 4.42]
1.3 Penicillin plus beta‐lactamase inhibitor versus penicillins	2	155	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.39, 3.93]
1.4 Penicillin plus beta‐lactamase inhibitor versus carbapenems	1	238	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.90, 1.05]
1.5 Penicillin plus beta‐lactamase inhibitor versus nitroimidazoles	1	67	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.24, 5.04]
2 Severe complication	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides	3	160	Risk Ratio (M‐H, Fixed, 95% CI)	4.32 [0.51, 36.95]
2.2 Penicillin plus beta‐lactamase inhibitor versus penicillin	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Wound infection	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides	1	77	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 Penicillin plus beta‐lactamase inhibitor versus penicillin	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.02, 7.47]
4 Allergic reaction	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides	2	124	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 Penicillin plus beta‐lactamase inhibitor versus penicillin	2	155	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.06, 15.23]
5 Diarrhea	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides	3	160	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.29, 4.01]
5.2 Penicillin plus beta‐lactamase inhibitor versus cephalosporins	1	27	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.06, 5.26]
5.3 Penicillin plus beta‐lactamase inhibitor versus penicillin	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Length of stay	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 Penicillin plus beta‐lactamase inhibitor versus penicillin	1	99	Mean Difference (IV, Fixed, 95% CI)	0.80 [‐0.09, 1.69]