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. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3

Comparison 3. Beta‐lactamase inhibitor combination versus any other regimen.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Treatment failure 12   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides 6 495 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.70, 1.64]
1.2 Penicillin plus beta‐lactamase inhibitor versus cephalosporins 2 52 Risk Ratio (M‐H, Fixed, 95% CI) 1.08 [0.26, 4.42]
1.3 Penicillin plus beta‐lactamase inhibitor versus penicillins 2 155 Risk Ratio (M‐H, Fixed, 95% CI) 1.24 [0.39, 3.93]
1.4 Penicillin plus beta‐lactamase inhibitor versus carbapenems 1 238 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.90, 1.05]
1.5 Penicillin plus beta‐lactamase inhibitor versus nitroimidazoles 1 67 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.24, 5.04]
2 Severe complication 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides 3 160 Risk Ratio (M‐H, Fixed, 95% CI) 4.32 [0.51, 36.95]
2.2 Penicillin plus beta‐lactamase inhibitor versus penicillin 1 56 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Wound infection 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides 1 77 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 Penicillin plus beta‐lactamase inhibitor versus penicillin 1 56 Risk Ratio (M‐H, Fixed, 95% CI) 0.41 [0.02, 7.47]
4 Allergic reaction 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides 2 124 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Penicillin plus beta‐lactamase inhibitor versus penicillin 2 155 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.06, 15.23]
5 Diarrhea 5   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Penicillin plus beta‐lactamase inhibitor versus lincosamides 3 160 Risk Ratio (M‐H, Fixed, 95% CI) 1.08 [0.29, 4.01]
5.2 Penicillin plus beta‐lactamase inhibitor versus cephalosporins 1 27 Risk Ratio (M‐H, Fixed, 95% CI) 0.54 [0.06, 5.26]
5.3 Penicillin plus beta‐lactamase inhibitor versus penicillin 1 56 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Length of stay 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 Penicillin plus beta‐lactamase inhibitor versus penicillin 1 99 Mean Difference (IV, Fixed, 95% CI) 0.80 [‐0.09, 1.69]