| Methods |
Randomized trial
Study period: April through October 1982 |
| Participants |
Inclusion criteria: clinical diagnosis of postpartum endometritis, salpingitis, or pelvic cellulitis after hysterectomy, all with oral temperature of 38 °C or higher, leukocytosis, and local tenderness
Setting: county hospital, San Antonio, Texas, USA
Number of participants: n = 77 (69 postcesarean birth) |
| Interventions |
Ceftazidime 2 g iv every 8 hours vs clindamycin 600 mg iv every 8 hours plus gentamicin 1.5 mg/kg iv every 8 hours |
| Outcomes |
Treatment failure
Complications including wound infections, allergic reactions, and diarrhea
Mean length of stay |
| Notes |
For the outcome of allergy, postcesarean birth participants were not analyzed separately
Pharmaceutical sponsorship ‐ explicit |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Random schedule provided by pharmaceutical sponsor. No specific methods described |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
“Not blinded” in the methods |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Not blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No drop‐outs |
| Selective reporting (reporting bias) |
Unclear risk |
The protocol is not available, insufficient information to permit judgement |
| Other bias |
High risk |
Sponsored by pharmaceutical company, Glaxo |
