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. 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3

Hager 1989.

Methods Randomized trial
 Study period: not given
Participants Inclusion criteria: women treated for chorioamnionitis, postpartum endometritis (defined as temperature of at least 38.1 °C, leukocytosis 15,000/mL, and uterine tenderness), or post hysterectomy cellulitis. All had received standard parenteral antibiotics until 48‐72 hours afebrile and clinically well
 Setting: Lexington, Kentucky, USA
 Number of participants: n = 163 evaluated, n = 81 with postpartum endometritis
Interventions Oral ampicillin 500 mg every 6 hours or tetracycline 500 mg every 6 hours (if penicillin allergic) to complete 10 days total of antibiotic therapy (n = 38) vs no treatment after iv antibiotics (n = 43)
Outcomes Further treatment with antibiotics by the time of follow up at 2‐4 weeks after hospital discharge
 Postdischarge infections (wound or urinary tract infection) classified as failures
Notes Information on route of delivery was not given
 Pharmaceutical sponsorship ‐ none apparent
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk States “random” without further description
Allocation concealment (selection bias) Unclear risk Not stated
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk States “single‐blinded study” in abstract but no further description
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk “The physician evaluating the patient at the follow‐up examination [..] was blinded as to whether they had taken the oral antibiotic or not:” Outcome assessor was blinded
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 163 (80%) out of 204 women were evaluated. 31 had no follow‐up visits, 10 had infection at other organ sites
Selective reporting (reporting bias) Unclear risk The protocol is not available, insufficient information to permit judgement
Other bias Low risk Study appeared to be free of other sources of bias