Ledger 1974.

Methods	Randomized trial Time period: 28 Oct 1971 through 28 July 1972
Participants	Inclusion criteria: clinically "severe" obstetric/gynecologic infections that required parenteral antibiotics as deemed by attending or resident physician Site: University of Michigan Hospital, USA Number of participants: n = 44
Interventions	Clindamycin varied dosage every 6‐8 hours with kanamycin 0.5 mg every 12 hours (n = 21) vs penicillin G 5‐10 million units every 6‐8 hours with kanamycin every 12 hours (n = 23)
Outcomes	Treatment failure, additional therapy required (antibiotic usage or surgical intervention), bacterial species identified
Notes	Pharamceutical sponsorship: Upjohn Did not provide data separately for those patients with endometritis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomized blocks of 10 envelopes
Allocation concealment (selection bias)	Low risk	Sealed numbered envelopes utilized
Blinding of participants and personnel (performance bias) All outcomes	High risk	Initial selection was blinded, but both physician and patient were privy to the treatment at the time of administration
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding for outcomes noted
Incomplete outcome data (attrition bias) All outcomes	Low risk	No drop outs
Selective reporting (reporting bias)	Low risk	It appears as though all outcomes were reported
Other bias	Low risk	‐