| Methods |
Randomized trial
Study period: December 1998 through December 2000 |
| Participants |
Inclusion criteria: temperature of at least 100.4 °F (38 °C) on at least 2 occasions 6 hours apart after the first 12 hours postpartum or greater than 101.5 °F (38.05 °C) at any time, no other evident source of infection, uterine tenderness or diagnosis of chorioamnionitis before birth thought to require antibiotics postpartum
Setting: University of Tennessee Health Science Center, USA
Number of participants: n = 112 |
| Interventions |
Gentamicin 5 mg/kg plus clindamycin 2700 mg iv once daily (n = 55) vs gentamicin 1.5 mg/kg plus clindamycin 900 mg every 8 hours (n = 55) |
| Outcomes |
Treatment failure
Length of hospital stay |
| Notes |
40 women undergoing cesarean were in the thrice‐daily dosing group and 46 in the once‐daily group |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
“Random” without further description |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
“Double‐blinded study” in methods but no further description. Probably done |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
Not stated |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
110 (98%) were evaluated |
| Selective reporting (reporting bias) |
Unclear risk |
The protocol is not available, insufficient information to permit judgment |
| Other bias |
Low risk |
Study appeared to be free of other sources of bias |
